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An investigation of structure activity effects of D-ring substitution of estradiol on estrogen receptor affinity
The 16α-alkylation was achieved via treatment of 3-methoxyestra-1,3,5(10)-trien-17-one-N,N-dimethylhydrazone (118) with n-butyllithium and the appropriate haloalkane to afford exclusive 16α-substitution (119). Subsequent, cupric ion-catalysed hydrolysis, 17-ketone reduction and removal of the 3-hydr...
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| Format: | Default Thesis |
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1992
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| Online Access: | https://hdl.handle.net/2134/28192 |
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