Development and characterization of a porcine mitral valve scaffold for tissue engineering

Decellularized scaffolds represent a promising alternative for mitral valve (MV) replacement. This work developed and characterized a protocol for the decellularization of whole MVs. Porcine MVs were decellularized with 0.5% (w/ v) SDS and 0.5% (w/v) SD and sterilized with 0.1% (v/v) PAA. Decellular...

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Bibliographic Details
Main Authors: M. Granados, Lucrezia Morticelli, S. Andriopoulou, P. Kalozoumis, Michael Pflaum, P. Iablonskii, B. Glasmacher, M. Harder, J. Hegermann, C. Wrede, I. Tudorache, S. Cebotari, Andres Hilfiker, Axel Haverich, Sotiris Korossis
Format: Default Article
Published: 2017
Subjects:
Mechanical engineering not elsewhere classified
Mitral valve
Heart valve replacement
Decellularization
Biomechanics
Histology
Immunohistochemistry
Biochemistry
α-Gal
Xenoepitope
Collagen IV
Biocompatibility
Tissue engineering
Scaffold
Transmission electron microscopy
Scanning electron microscopy
Cytotoxicity
Scaffold seeding
Human foreskin fibroblasts
Humanadipose-derived stem cells
Human colony-forming endothelial cells
Mechanical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/37014
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