Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture

Aim: Commercial regenerative medicine will require large quantities of clinical-specification human cells. The cost and quality of manufacture is notoriously difficult to control due to highly complex processes with poorly defined tolerances. As a step to overcome this, we aimed to demonstrate the u...

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Bibliographic Details
Main Authors: Elizabeth Ratcliffe, Paul Hourd, Juan-Jose Guijarro-Leach, Erin Rayment, David Williams, Rob Thomas
Format: Default Article
Published: 2013
Subjects:
Mechanical engineering not elsewhere classified
Automation
Cost of goods
Human embryonic stem cell
Manufacture
Process control
Response surface methodology
Scalability
Mechanical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/13171
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