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Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity
Purpose An elevated prevalence of sleep apnoea (SA) in patients with acromegaly has been suggested. Methods We performed polysomnographies in 52 patients with acromegaly (25 m, 27 f, age 51 years, range 19-82 years). Patients were defined having SA if they had more than five apnoeas or hypopnoeas pe...
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Published in: | Sleep & breathing 2012-12, Vol.16 (4), p.1247-1253 |
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creator | Roemmler, J. Gutt, B. Fischer, R. Vay, S. Wiesmeth, A. Bidlingmaier, M. Schopohl, J. Angstwurm, M. |
description | Purpose
An elevated prevalence of sleep apnoea (SA) in patients with acromegaly has been suggested.
Methods
We performed polysomnographies in 52 patients with acromegaly (25 m, 27 f, age 51 years, range 19-82 years). Patients were defined having SA if they had more than five apnoeas or hypopnoeas per hour (respiratory disturbance index = RDI). The type of SA was divided into obstructive (OSA), central (CSA) or mixed (OSA+CSA). Seventeen patients had newly diagnosed disease, and 18 patients were treated with somatostatin analogues.
Results
Twenty-three patients had controlled disease activity (mean GH levels |
doi_str_mv | 10.1007/s11325-011-0641-7 |
format | article |
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An elevated prevalence of sleep apnoea (SA) in patients with acromegaly has been suggested.
Methods
We performed polysomnographies in 52 patients with acromegaly (25 m, 27 f, age 51 years, range 19-82 years). Patients were defined having SA if they had more than five apnoeas or hypopnoeas per hour (respiratory disturbance index = RDI). The type of SA was divided into obstructive (OSA), central (CSA) or mixed (OSA+CSA). Seventeen patients had newly diagnosed disease, and 18 patients were treated with somatostatin analogues.
Results
Twenty-three patients had controlled disease activity (mean GH levels <1 μg/l during a 3-h profile and normalised IGF-1 levels). Twelve had active acromegaly despite medical treatment. Thirty patients (58%) had SA. Twenty-five of those had OSA, three had CSA, and two had mixed. Of the patients with active disease, 66% had SA, compared to 48% in the cured group. Significantly more patients with hypertension (
n
= 18) than without hypertension (
n
= 12,
p
= 0.041) had SA. Basal glucose was not significantly different between patients with (100 mg/dl, range 75–207 mg/dl) and without SA (92 mg/dl, range 74–120 mg/dl), but HbA1c was significantly higher in patients with SA (5.9% (4.9–9.0%) vs. 5.4% (4.3–6.1%),
p
= 0.001). A positive correlation between RDI and BMI (
p
= 0.04), RDI and age (
p
= 0.013) and RDI and disease activity (
p
= 0.014) was seen. No major correlation could be found between RDI and the duration of disease activity nor between RDI and GH levels.
Conclusion
RDI correlates positively with disease activity but not with the duration of the disease. The parameters of the metabolic syndrome are positively associated to the degree of SA in acromegalic patients.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-011-0641-7</identifier><identifier>PMID: 22241151</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acromegaly - diagnosis ; Acromegaly - epidemiology ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Body mass index ; Cross-Sectional Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dentistry ; Disease ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Female ; Fundamental and applied biological sciences. Psychology ; Germany ; Growth hormones ; Humans ; Incidence ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Original Article ; Otorhinolaryngology ; Pediatrics ; Pituitary gland ; Pneumology/Respiratory System ; Polysomnography ; Risk Factors ; Sleep apnea ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - epidemiology ; Sleep. Vigilance ; Statistics as Topic ; Vertebrates: nervous system and sense organs ; Young Adult</subject><ispartof>Sleep & breathing, 2012-12, Vol.16 (4), p.1247-1253</ispartof><rights>Springer-Verlag 2012</rights><rights>2014 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-90a951649913b01a4b0a1423691e24974c2227eab82859fff9d02619be3872e83</citedby><cites>FETCH-LOGICAL-c402t-90a951649913b01a4b0a1423691e24974c2227eab82859fff9d02619be3872e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1151806104/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1151806104?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21394,27924,27925,33611,33612,43733,74221</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26645441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22241151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roemmler, J.</creatorcontrib><creatorcontrib>Gutt, B.</creatorcontrib><creatorcontrib>Fischer, R.</creatorcontrib><creatorcontrib>Vay, S.</creatorcontrib><creatorcontrib>Wiesmeth, A.</creatorcontrib><creatorcontrib>Bidlingmaier, M.</creatorcontrib><creatorcontrib>Schopohl, J.</creatorcontrib><creatorcontrib>Angstwurm, M.</creatorcontrib><title>Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Purpose
An elevated prevalence of sleep apnoea (SA) in patients with acromegaly has been suggested.
Methods
We performed polysomnographies in 52 patients with acromegaly (25 m, 27 f, age 51 years, range 19-82 years). Patients were defined having SA if they had more than five apnoeas or hypopnoeas per hour (respiratory disturbance index = RDI). The type of SA was divided into obstructive (OSA), central (CSA) or mixed (OSA+CSA). Seventeen patients had newly diagnosed disease, and 18 patients were treated with somatostatin analogues.
Results
Twenty-three patients had controlled disease activity (mean GH levels <1 μg/l during a 3-h profile and normalised IGF-1 levels). Twelve had active acromegaly despite medical treatment. Thirty patients (58%) had SA. Twenty-five of those had OSA, three had CSA, and two had mixed. Of the patients with active disease, 66% had SA, compared to 48% in the cured group. Significantly more patients with hypertension (
n
= 18) than without hypertension (
n
= 12,
p
= 0.041) had SA. Basal glucose was not significantly different between patients with (100 mg/dl, range 75–207 mg/dl) and without SA (92 mg/dl, range 74–120 mg/dl), but HbA1c was significantly higher in patients with SA (5.9% (4.9–9.0%) vs. 5.4% (4.3–6.1%),
p
= 0.001). A positive correlation between RDI and BMI (
p
= 0.04), RDI and age (
p
= 0.013) and RDI and disease activity (
p
= 0.014) was seen. No major correlation could be found between RDI and the duration of disease activity nor between RDI and GH levels.
Conclusion
RDI correlates positively with disease activity but not with the duration of the disease. The parameters of the metabolic syndrome are positively associated to the degree of SA in acromegalic patients.</description><subject>Acromegaly - diagnosis</subject><subject>Acromegaly - epidemiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body mass index</subject><subject>Cross-Sectional Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dentistry</subject><subject>Disease</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germany</subject><subject>Growth hormones</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Pituitary gland</subject><subject>Pneumology/Respiratory System</subject><subject>Polysomnography</subject><subject>Risk Factors</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Sleep. Vigilance</subject><subject>Statistics as Topic</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Young Adult</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>M2R</sourceid><recordid>eNp1kNtKxDAQhoMonh_AGymI4E11Jk0PuRTxBIIgeh2m7XTp0m3WpCvsnQ_hE_okZt31gODVBOabmT-fEAcIpwiQn3nERKYxIMaQKYzzNbGNqZQx5qDXP98Q6xTlltjxfgyAqtC4KbaklAoxxW3xcNnxCw1cR21ftTX3FUe2iXzHPI1o2lum0ImocnbCI-rm769vlXWOOxpa20eDjerWM3kOzNC-tMN8T2w01HneX9Vd8XR1-XhxE9_dX99enN_FlQI5xBooRMuU1piUgKRKIFQyyTSyVDpXVUiZM5WFLFLdNI2uQWaoS06KXHKR7IqT5d6ps88z9oOZtL7irqOe7cwbxByLAtMEAnr0Bx3bmetDOrPQUECGoAKFSyp81nvHjZm6dkJubhDMQrhZCjdBuFkIN3mYOVxtnpUTrr8nvgwH4HgFkK-oaxwFz_6HyzKVKrXg5JLzodWP2P2K-O_1D8fnlrI</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Roemmler, J.</creator><creator>Gutt, B.</creator><creator>Fischer, R.</creator><creator>Vay, S.</creator><creator>Wiesmeth, A.</creator><creator>Bidlingmaier, M.</creator><creator>Schopohl, J.</creator><creator>Angstwurm, M.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity</title><author>Roemmler, J. ; Gutt, B. ; Fischer, R. ; Vay, S. ; Wiesmeth, A. ; Bidlingmaier, M. ; Schopohl, J. ; Angstwurm, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-90a951649913b01a4b0a1423691e24974c2227eab82859fff9d02619be3872e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acromegaly - diagnosis</topic><topic>Acromegaly - epidemiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body mass index</topic><topic>Cross-Sectional Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dentistry</topic><topic>Disease</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Germany</topic><topic>Growth hormones</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Pituitary gland</topic><topic>Pneumology/Respiratory System</topic><topic>Polysomnography</topic><topic>Risk Factors</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>Sleep. Vigilance</topic><topic>Statistics as Topic</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roemmler, J.</creatorcontrib><creatorcontrib>Gutt, B.</creatorcontrib><creatorcontrib>Fischer, R.</creatorcontrib><creatorcontrib>Vay, S.</creatorcontrib><creatorcontrib>Wiesmeth, A.</creatorcontrib><creatorcontrib>Bidlingmaier, M.</creatorcontrib><creatorcontrib>Schopohl, J.</creatorcontrib><creatorcontrib>Angstwurm, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Social Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roemmler, J.</au><au>Gutt, B.</au><au>Fischer, R.</au><au>Vay, S.</au><au>Wiesmeth, A.</au><au>Bidlingmaier, M.</au><au>Schopohl, J.</au><au>Angstwurm, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>16</volume><issue>4</issue><spage>1247</spage><epage>1253</epage><pages>1247-1253</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Purpose
An elevated prevalence of sleep apnoea (SA) in patients with acromegaly has been suggested.
Methods
We performed polysomnographies in 52 patients with acromegaly (25 m, 27 f, age 51 years, range 19-82 years). Patients were defined having SA if they had more than five apnoeas or hypopnoeas per hour (respiratory disturbance index = RDI). The type of SA was divided into obstructive (OSA), central (CSA) or mixed (OSA+CSA). Seventeen patients had newly diagnosed disease, and 18 patients were treated with somatostatin analogues.
Results
Twenty-three patients had controlled disease activity (mean GH levels <1 μg/l during a 3-h profile and normalised IGF-1 levels). Twelve had active acromegaly despite medical treatment. Thirty patients (58%) had SA. Twenty-five of those had OSA, three had CSA, and two had mixed. Of the patients with active disease, 66% had SA, compared to 48% in the cured group. Significantly more patients with hypertension (
n
= 18) than without hypertension (
n
= 12,
p
= 0.041) had SA. Basal glucose was not significantly different between patients with (100 mg/dl, range 75–207 mg/dl) and without SA (92 mg/dl, range 74–120 mg/dl), but HbA1c was significantly higher in patients with SA (5.9% (4.9–9.0%) vs. 5.4% (4.3–6.1%),
p
= 0.001). A positive correlation between RDI and BMI (
p
= 0.04), RDI and age (
p
= 0.013) and RDI and disease activity (
p
= 0.014) was seen. No major correlation could be found between RDI and the duration of disease activity nor between RDI and GH levels.
Conclusion
RDI correlates positively with disease activity but not with the duration of the disease. The parameters of the metabolic syndrome are positively associated to the degree of SA in acromegalic patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22241151</pmid><doi>10.1007/s11325-011-0641-7</doi><tpages>7</tpages></addata></record> |
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subjects | Acromegaly - diagnosis Acromegaly - epidemiology Adult Aged Aged, 80 and over Biological and medical sciences Body mass index Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dentistry Disease Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Fundamental and applied biological sciences. Psychology Germany Growth hormones Humans Incidence Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Nervous system (semeiology, syndromes) Neurology Original Article Otorhinolaryngology Pediatrics Pituitary gland Pneumology/Respiratory System Polysomnography Risk Factors Sleep apnea Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - epidemiology Sleep. Vigilance Statistics as Topic Vertebrates: nervous system and sense organs Young Adult |
title | Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity |
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