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Ni-Catalyzed Protecting Group Free Diphenic Acid Analog Synthesis
Severe side effects and drug resistance are major drawbacks of Pt-based chemotherapy in clinical practice, leading to the search for new Pt-based drugs through the tuning of coordination ligands. Therefore, seeking appropriate ligands has attracted significant interest in this area. In this study, w...
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Published in: | Organic letters 2023-06, Vol.25 (25), p.4700-4704 |
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container_end_page | 4704 |
container_issue | 25 |
container_start_page | 4700 |
container_title | Organic letters |
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creator | Zhao, Bo-Wei Yang, Liu Long, Cheng-Yu Li, Han-Lu He, Yu-Ting Wang, Xue-Qiang |
description | Severe side effects and drug resistance are major drawbacks of Pt-based chemotherapy in clinical practice, leading to the search for new Pt-based drugs through the tuning of coordination ligands. Therefore, seeking appropriate ligands has attracted significant interest in this area. In this study, we report a Ni-catalyzed coupling strategy for the divergent synthesis of diphenic acid derivatives and the application of these newly prepared acids in Pt(II) agent synthesis. |
doi_str_mv | 10.1021/acs.orglett.3c01625 |
format | article |
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language | eng |
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source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
subjects | Biphenyl Compounds Catalysis Ligands |
title | Ni-Catalyzed Protecting Group Free Diphenic Acid Analog Synthesis |
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